Myrl Jeffcoat myrlj@jps.net

17 mars, 2005 20:27

Several sisters are on the Avonex regimen --- and possibly have not known this.? 

MedWatch - The FDA Safety Information and Adverse Event Reporting Program

FDA and Biogen notified healthcare professionals of revisions to the WARNINGS, PRECAUTIONS/Drug Interactions and ADVERSE REACTIONS/Post-Marketing Experience sections and Medication Guide. Severe hepatic injury, including cases of hepatic failure, has been reported in patients taking Avonex. Asymptomatic elevation of hepatic transaminases has also been reported, and in some patients has recurred upon rechallenge. In some cases, these events have occurred in the presence of other drugs that have been associated with hepatic injury. The potential risk of Avonex used in combination with known hepatotoxic drugs or other products (e.g. alcohol) should be considered prior to Avonex administration, or when adding new agents to the regimen of patients already on Avonex.

Read the complete MedWatch 2005 Safety Summary, with links to the Dear Healthcare Professional letter and revised label, at: