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Posted on dimanche 29 avril 2007 (EST)

A recent research has found that a drug commonly used to treat toenail fungus can also block angiogenesis, the growth of new blood vessels commonly seen in cancers.

Washington, April 29 (ANI): A recent research has found that a drug commonly used to treat toenail fungus can also block angiogenesis, the growth of new blood vessels commonly seen in cancers.

Researchers at Johns Hopkins have discovered that in mice, induced to have excess blood vessel growth, treatment with itraconazole reduced blood vessel growth by 67 percent compared to placebo.

"We were surprised, to say the least, that itraconazole popped up as a potential blocker of angiogenesis," says Jun O. Liu, Ph.D., professor of pharmacology. "We couldn’t have predicted that an antifungal drug would have such a role."

In their hunt for antiangiogenesis drugs, the researchers worked with cells from human umbilical cords, a rich source of blood vessels.

They exposed the cells to 2,400 existing drugs, including FDA and foreign-approved drugs, as well as non-approved drugs that had passed safety trials, to make out which ones could stop the cells from dividing.

"The best outcome was to find an already approved drug that worked, and the fact that we did was very satisfying," says Liu, whose study appears online in ACS Chemical Biology.

As an antifungal drug, itraconazole obstructs a key enzyme for making fungal cholesterol, causing these primitive life forms to become brittle and split apart.

It turns out that itraconazole can block the same enzyme in blood vessels, but the researchers aren’t sure if that’s the reason blood vessels stop growing, because related antifungal drugs had much lower inhibitory effect.

"Our screening test did show that cholesterol-lowering statins also appear to stop blood vessel growth," Liu says, "so there is likely some important connection between cholesterol and angiogenesis."

While the researchers still must get to the bottom of exactly how itraconazole works to stop vessel growth, and test it in animals with cancer, they have high hopes for its use.

"Itraconazole can be taken orally for fungal infection, and therefore oral delivery may work for angiogenesis as well," Liu notes. (ANI)