Jussta
jussta@jussta.com17 janvier, 2008 22:16
Silicone Macrophages & Inflammatory Response
Here is an excerpt from my web research on Silicone Macrophages. I have maintained this was happening for years...well, good some scientist is finally proving it. This is why I believe that ANY surgery, disease onset, or injury causes the "Silicone Macrophages" to attack the site of the injury, surgery - etc, thinking it is silicone, thus inflaming the site and causing more "silicone macrophages" to be created by the body.
Background
intraperitoneal (i.p.) injection of dimethylpolysiloxane (DMPS) (silicone). We studied the expression of adhesion and co-stimulatory molecules and boththe spontaneous and the stimulated production of reactive oxygenintermediates and nitric oxide (NO).
Results
Conclusions
Background
[1 <
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237#B1> ].Medical-grade silicones consist primarily of dimethylpolysiloxane (DMPS) and are widely used in devices including cardiac valves, intravenous tubing,intraocular lenses, digital joint arthroplasty prostheses, breast implants,syringes, needles, baby bottle nipples and many others products
[2<
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237#B1> ].Depending upon the length of the polymer chains and the amount ofcross-linking between chains medical-grade silicones can be found as fluids,gels or elastomers.
The effect of silicones on the immune function is not fully characterized.
It has been shown that certain forms of silicone are immunologically active.
[3 <
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237#B2> ].and depending upon the molecular weight and the degree of cross-linking of the polymers, silicones are potent humoral adjuvants
[4 <
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237#B3> ].Several studies of the silicone-induced inflammatory response in patients and animals revealed histopathological findings instead of direct evidences of cellular activation
[5 <
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237#B4> -].[6 <
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237#B6> ].The initial body's reaction to the implanted material is the inflammatory response that induces recruitment and activation of different cells
[7 <
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237#B7> ].The magnitude of any inflammatory response can be related to the level of activation of macrophages. This activation occurs both in inflammatory andin adaptive immune responses, and involves phenotypic and functional changes
[8 <
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237#B8> ].Criteria widely used for activation are the ability to inhibit intracellularproliferation of microorganisms, the increased production of reactive oxygenintermediates and the enhanced expression of MHC and co-stimulatorymolecules
[9 <
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237#B9> ].[10 <
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237#B10> ].Recently, Naim et al. showed that silicone elastomer preadsorbed with plasma proteins activated human monocytes in vitro to secrete pro-inflammatory cytokines
[11 <
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237#B11> ].Besides, silicone gels and oils activated macrophages in female A.SW mice: increased production of IL-6 and IL-1β was obtained from macrophagescollected from silicone fluid- and silicone oil-treated mice when cultured with increasing am
ounts of lipopolysaccharide[12 <
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237#B12> ].From the website:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117237
"Fear knocked on the door: Faith opened it, and there was no one there!" ~
Jussta Thought
Love, Light, and Blessings All Ways, Jussta
