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PUTTING BREAKING MEDICAL NEWS INTO PRACTICE^™

Monday March 31, 2008

TODAY'S HEADLINES
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For the latest news, features, columns, video and audio reports and more, visit our home page at www.medpagetoday.com

ACC: ENHANCE Data on Ezetimibe/Simvastatin (Vytorin) Reveal Wavy Bottom Line

CHICAGO -- A full-airing here today of findings of the ENHANCE trial did nothing to blunt the null finding for the combination of ezetimibe/simvastatin (Vytorin) that was prefaced in a preliminary press release in January. full story

http://www.medpagetoday.com/MeetingCoverage/ACCMeeting/tb/8953

ACC: Manual Clot Removal Boosts Clinical Benefit of PCI in Acute MI

CHICAGO -- Thrombus aspiration during percutaneous coronary intervention may reduce mortality and improve long-term clinical outcomes, Dutch researchers said here. full story

http://www.medpagetoday.com/MeetingCoverage/ACCMeeting/tb/8952

ACC: Both Tirofiban and Abciximab Work

CHICAGO -- High-dose bolus tirofiban (Aggrastat) was as effective as abciximab (ReoPro) infusion in achieving fast resolution of acute MI, but both strategies had a better outcome when used with a drug-eluting stent. full story

http://www.medpagetoday.com/MeetingCoverage/ACCMeeting/tb/8950

ACC: Recurrent Stent Thromboses Common

CHICAGO -- Nearly one in every five patients (18.8%) who had a first stent thrombosis had another one within three years, a multicenter observational study found. full story

http://www.medpagetoday.com/MeetingCoverage/ACCMeeting/tb/8949

ACC: Sudden Death May Follow on Anniversary of Parent’s Demise

CHICAGO -- The anniversary of the loss of a parent may cause enough distress to trigger sudden death, especially in men, researchers found. full story

http://www.medpagetoday.com/MeetingCoverage/ACCMeeting/tb/8948

ENHANCE: More Data but Still No Answers
CHICAGO, March 30 -- In this exclusive MedPage Today broadcast of an American College of Cardiology showcase, ENHANCE investigators finally report full data from the study that found no evidence that ezetimibe/simvastatin (Vytorin) slowed progression of atherosclerosis. full story

http://www.medpagetoday.com/MeetingCoverage/ACCMeeting/tb/8945

ACC: Persistent Smoking After MI Puts Young at High Risk for Recurrence

CHICAGO -- Young smokers who don’t quit after having an acute MI are more than twice as likely to have another event as those who stop smoking, Greek researchers found. full story

http://www.medpagetoday.com/MeetingCoverage/ACCMeeting/tb/8942

ACC: Bivalirudin Shows No Net Clinical Benefit for Low-Risk Patients

CHICAGO -- Bivalirudin (Angiomax) may improve bleeding but not overall outcomes compared with unfractionated heparin for patients with low-risk acute coronary syndrome undergoing percutaneous intervention, researchers reported here. full story

http://www.medpagetoday.com/MeetingCoverage/ACCMeeting/tb/8947

ACC: Huge Study Gives Safety Endorsement to PCI Without On-Site Surgical Backup

CHICAGO -- Percutaneous coronary intervention (PCI) without on-site surgical backup appears to be safe, according to a study reported here of more than 300,000 patients at 465 centers. full story

http://www.medpagetoday.com/MeetingCoverage/ACCMeeting/tb/8943

What’s Creating the Buzz at ACC.08?
Chicago -- In this exclusive MedPage Today broadcast from the American College of Cardiology meeting, researchers report low efficacy of flu shots in heart failure patients as well as increased cardiac risk from anxiety, smoking, obesity, and even the anniversary of a loved one’s death. full story

http://www.medpagetoday.com/MultiMedia/MultiMedia/tb/8868

ACC: Prasugrel Reduces Thrombosis Across Stent Types

CHICAGO -- The investigational antiplatelet agent prasugrel consistently improves ischemic event rates after percutaneous coronary intervention, whatever type of stent is used, researchers found. full story

http://www.medpagetoday.com/MeetingCoverage/ACCMeeting/tb/8944

Podcast: Strategies to Help Patients Fight the Battle of the Bulge

OAKLAND -- In this exclusive MedPage Today podcast, Keith Bachman, M.D., of Kaiser Permanente in Portland, Ore., discusses ways to help patients trim off the belly fat that’s now been linked to dementia as well as heart disease and diabetes. full story

http://www.medpagetoday.com/PrimaryCare/Obesity/tb/8926

PTSD Increases Hospitalization Rates in Urban Poor

BOSTON -- Posttraumatic stress disorder (PTSD) is common among poor, urban residents and those who suffer it have more and longer hospital stays, researchers here said. full story

http://www.medpagetoday.com/Psychiatry/AnxietyStress/tb/8940

Haloperidol Holds Its Own Against Second-Generation Antipsychotics for Schizophrenia

UTRECHT, The Netherlands -- For a first episode of schizophrenia, four second-generation antipsychotics were no more effective than haloperidol, but they did have lower discontinuation rates, an open, randomized trial showed. full story

http://www.medpagetoday.com/Psychiatry/Schizophrenia/tb/8941

AIDS Lobby Group and CDC Clash on Meaning of New HIV Numbers
LOS ANGELES -- An AIDS lobby group accused the CDC today of "stonewalling" on data that purportedly show a 48% one-year jump in new HIV infections. The CDC responded that the lobby group misinterpreted the data. full story

http://www.medpagetoday.com/HIVAIDS/HIVAIDS/tb/8939

Parkinson’s Association with Pesticide Exposure Gains Strength

MIAMI -- Pesticide exposure may boost the risk of developing Parkinson’s disease over and above genetic factors, according to a case-control study here. full story

http://www.medpagetoday.com/Neurology/ParkinsonsDisease/tb/8915

Monocyte Subtype May Predict HIV Progression

PHILADELPHIA -- A subset of monocytes, the precursors of macrophages, may act as an early warning sign of HIV progression and a possible target for therapy, researchers here said. full story

http://www.medpagetoday.com/HIVAIDS/HIVAIDS/tb/8937

Aging Lungs Fail Faster with Type 2 Diabetes

BALTIMORE -- Lung function declines faster in type 2 diabetes patients than in those without the disease, researchers here said. full story

http://www.medpagetoday.com/Cardiology/Diabetes/tb/8936

Once-Daily Insulin More Convenient but No More Effective

GIESSEN, Germany -- Once-daily injections of insulin glargine (Lantus) may control type 2 diabetes as well as multiple injections of insulin lispro (Humalog) and reduce side effects at the same time, researchers here found. full story

http://www.medpagetoday.com/Nephrology/Diabetes/tb/8935

FDA Calls for Safety Plans for 25 Agents
ROCKVILLE, Md. -- The FDA has named 25 drugs and biologic products -- including some well-known medications -- whose makers will be required to submit safety plans later this year. full story

http://www.medpagetoday.com/ProductAlert/Prescriptions/tb/8934

PET Tracer Picks Up Alzheimer’s Plaques in Live Patient

PITTSBURGH -- Beta-amyloid plaques were successfully visualized with a PET scan in a living Alzheimer’s disease patient, researchers here said. full story

http://www.medpagetoday.com/Neurology/AlzheimersDisease/tb/8933

CME SPOTLIGHT

The Quest for Erythropoiesis: A Preoperative Red Blood Cell Production
This Web activity, featuring experts in the field of blood management, provides a data-driven approach to the preoperative management of anemia in patients undergoing elective surgery.
Source: AdvancMed [more]

Controversies and Consensus in the Management of HIV: Interactive Debates
Are NNRTI- or PI-based regimens the best choice for initial ARV therapy? If a patient is failing therapy, when should you switch? Do treatment experienced patients require 2 or 3 active ARV agents? Join us for thoughtful debates and lively discussion led by a panel of HIV experts.
Source: AdvancMed [more]

Targeted Cancer Therapy From Trial To Clinic
Join Drs. Balducci, Atkins, Cantley, and Herbst for an innovative and in-depth CME-certified Activity on how integration of targeted and conventional therapies for treating cancer is improving patient outcomes.
Source: The Physicians Academy For Clinical and Management Excellence [more]

New phase 3 trials may dramatically alter the management of newly diagnosed myeloma.
This activity reviews these trials as well as new developments in transplantation and relapsed/refractory therapies.
Source: Curatio CME Institute [more]

Managing the Symptomatic Menopausal Patient in Primary Care: A Case-Based Approach
This interactive CME activity provides practical recommendations and the latest clinical evidence to improve the personalized care a women receives during menopause.
Source: Interstate Postgraduate Medical Association and MEV Healthcom, Inc. [more]

MRI Evaluation of the Contralateral Breast in Women with Recently Diagnosed Breast Cancer
In this free CME/CE/CPE article review, William J. Gradishar, MD, discusses how early use of MRI in women with recently diagnosed unilateral breast cancer can improve detection of tumors in the contralateral breast.
Source: Projects In Knowledge [more]

Genital HPV and HPV Vaccines: Winning acceptance among adolescents and their parents
HPV is a highly prevalent sexually transmitted infection, most common in sexually active women under the age of 25. The following free educational activity is designed to educate physicians about the most common types of genital HPV and review the safety and efficacy of utilizing HPV vaccines.
Source: SciMed New York [more]

Treating Major Depression: From Remission to Long-Term Recovery
In the following certified program, Dr. John Rush uses evidence-based clinical trial data to illustrate the value of long-term treatment outcomes on major depressive disorder patients and the effectiveness of the latest treatment options available.
Source: The University of Pennsylvania School of Medicine [more]

JOURNAL DOWNLOADS

Efficacy Data for CTCL Published in JCO
Efficacy Data for CTCL Published in JCO. Source: Merck. [more]

RESOURCES

Why not provide greater LDL-C efficacy for your appropriate newly initiated patients?
View the data on 50% mean reduction right from the start. Source: Merck [more]

Now Approved: A new development in the treatment of hypertension.
Now approved from Forest Laboratories: Bystolic (nebivolol). A novel beta blocker for the treatment of hypertension. Click here to learn more. Source: Forest Labs [more]

Take a closer look at all 3 major lipids and cardiovascular risk. HDL, LDL and TG levels may be independently associated with cardiovascular risk.
Visit www.totallipds.com, a new source of information for health care professionals, about dyslipidemia, all 3 lipids, and cardiovascular risk. Source: Merck [more]

Explore the Possibilities in Type 2 Diabetes.
Type 2 diabetes studies: Understand mechanism of action for a different treatment option. Learn more today. Source: Merck [more]

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A teaching facility in upstate New York is seeking two urologists to place for clinic and call coverage.
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Visit MedJobs Today.com to search for a new job!

ASCO Meeting

ASCO: Neoadjuvant Bevacizumab (Avastin) Safe for Colorectal Cancer Liver Metastases

ASCO: African Americans Fare Worse in Bevacizumab (Avastin) Colorectal Cancer Study

ADA Meeting

ADA: Investigational Diabetes Drug Rids Glucose Via Urine

ICAAC Meeting

ICAAC: Tampon Coating Reduces Menstrual Toxic Shock Toxin

ICAAC: Day Care Safer Thanks to Vaccines

IASLC Meeting

IASLC: Hand-Rolled Cigarettes More Carcinogenic than Store Bought

Get tools, resources & information about Gleevec matching the experience of attendees of the 2007 ASH Annual Meeting.

Did you miss the Gleevec booth at the 2007 ASH Meeting? Get tools, resources and information about Gleevec via a fully interactive virtual exhibit booth, matching the experience of attendees of the 2007 ASH Annual Meeting.

Source: Novartis Oncology.

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