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Medical Studies/Trials News Experimental study on most common form of heart valve disease in Western countries may lead to new treatments
http://www.news-medical.net/?id=37510
A team of scientists from the University of Montreal and the Montreal Heart Institute Research Centre, led by Dr. Jean-Claude Tardif, has completed an important study that show how a new type of medication can lead to an improvement in the aortic valve narrowing
Iron nanoparticles spot tumor spread in patients with kidney cancer
http://www.news-medical.net/?id=37502
Iron nanoparticles designed to collect in lymph nodes containing metastatic cancer cells have proven that they can help physicians detect metastatic spread of prostate cancer.
Countries could save millions of Euros a year if follow-ups for breast cancer patients were led by specialist nurses rather than physicians
http://www.news-medical.net/?id=37497
Follow-up care for breast cancer patients costs less if it is conducted by nurses rather than physicians, yet there is no difference in the patients' anxiety, depression, satisfaction or outcome, according to research presented today (Friday) at the 6th European Breast Cancer Conference (EBCC-6) in Berlin.
Inhibiting stress oxidant may be new therapy for COPD
http://www.news-medical.net/?id=37496
The study "Oxidative Stress is an Important Component of Airway Inflammation in Mice Exposed to Cigarette Smoke or Lipopolysaccharide" investigates the inflammatory responses in oxidative stress-deficient mice exposed to cigarette smoke.
Herceptin and chemotherapy improves response rates without major adverse effects in HER2 breast cancer
http://www.news-medical.net/?id=37493
Women with a particularly aggressive form of breast cancer seem to do better if they are treated with a combined anthracycline and taxane chemotherapy regimen before surgery, together with trastuzumab (Herceptin) before and after surgery, according to results from the largest multi-centre trial to investigate this treatment.
First functional insulin-binding protein in invertebrates
http://www.news-medical.net/?id=37487
Insulin-like growth factor (IGF) signaling that helps to regulate mammals' growth, metabolism, reproduction and longevity is well documented. Now research published in the open access journal Journal of Biology describes the genetic identification of the first functional insulin-like growth factor binding protein (IGFBP) ortholog in invertebrates.
Naftidrofuryl for leg pain
http://www.news-medical.net/?id=37486
Patients with pain caused by narrowed arteries in their legs have 37% more pain-free walking if they take naftidrofuryl (200mg three times a day) than those taking placebos, a Cochrane Review has found.
Heparin versus placebo for acute coronary syndromes
http://www.news-medical.net/?id=37485
Compared with those on placebos, giving heparin to people who have heart conditions like unstable angina and some forms of heart attack reduces the risk of having another heart attack, concluded a Cochrane Systematic Review.
Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases
http://www.news-medical.net/?id=37484
Many people take antioxidants in the belief that they will prolong their life expectancy. However, data from 67 randomised trials that involved just under a quarter of a million people failed to support this idea, a Cochrane Systematic Review has discovered.
Huperzine A for Alzheimer's disease
http://www.news-medical.net/?id=37483
Existing evidence suggests that patients with Alzheimer's disease who have taken Huperzine A have improved general cognitive function, global clinical status, functional performance and reduced behavioural disturbance compared to patients taking placebos.
Dopamine agonists reduce motor complications in Parkinson's disease, but increase other side-effects
http://www.news-medical.net/?id=37482
Dopamine agonists are increasingly used to treat people with Parkinson's disease, but there is a debate about how well they work.
Five-alpha-reductase Inhibitors for prostate cancer prevention
http://www.news-medical.net/?id=37481
Compared to placebo treatment, taking 5-alpha-reductase inhibitors (5-ARIs) can reduce a man's risk of being diagnosed with prostate cancer from around 5-9% to around 4-6% during up to 7 years of treatment, according to a new Cochrane Review.
Antibiotics for acute maxillary sinusitis
http://www.news-medical.net/?id=37480
A Cochrane Systematic Review of medical research found that four out of five patients who are seen in primary care with simple sinusitis improved within two weeks even if they had not been given antibiotics.
Anti-cholinergic drugs may increase cognitive decline in older people
http://www.news-medical.net/?id=37471
Anticholinergic drugs, such as medicines for stomach cramps, ulcers, motion sickness, and urinary incontinence, may cause older people to experience greater decline in their thinking skills than people not taking the drugs, according to research that will be presented at the American Academy of Neurology 60th Anniversary Annual Meeting in Chicago, April 12-19, 2008.
New insights on early Parkinson's provided by advanced MRI
http://www.news-medical.net/?id=37470
Parkinson's disease is a degenerative disorder of the brain affecting movement, speech, mood, behavior, thinking and sensation for which there is no known cause or cure.
Study suggests that antidepressants could also be used for the treatment of amblyopia
http://www.news-medical.net/?id=37462
In the April 18 issue of Science, scientists from the Scuola Normale Superiore in Pisa, Italy and the Neuroscience Centre at the University of Helsinki, Finland, provide new information about the mechanism of action of antidepressant drugs.
Common hassles at work hamper sleep
http://www.news-medical.net/?id=37452
Common hassles at work are more likely than long hours, night shifts or job insecurity to follow workers home and interfere with their sleep.
Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment
http://www.news-medical.net/?id=37449
Aerobic exercise could give older adults a boost in brainpower, according to a recent review of studies from the Netherlands.
Flu vaccines can reduce respiratory problems by up to three-quarters
http://www.news-medical.net/?id=37448
Annual flu vaccinations are highly effective at preventing acute respiratory illness and making sure that existing breathing problems don't get any worse, according to research published in the April issue of IJCP, the UK-based International Journal of Clinical Practice.
FDA approves expansion of NeoVista's phase 3 study for wet AMD
http://www.news-medical.net/?id=37445
NeoVista, Inc. announced today that the U.S. Food and Drug Administration (FDA) has granted the company's request to expand the number of sites participating in its pivotal Phase 3 trial from 10 to 30 in the United States.
Heavy drinkers and smokers develop Alzheimer's earlier
http://www.news-medical.net/?id=37443
Heavy drinkers and heavy smokers develop Alzheimer's disease years earlier than people with Alzheimer's who do not drink or smoke heavily, according to research that will be presented at the American Academy of Neurology 60th Anniversary Annual Meeting in Chicago, April 12-19, 2008.
No link between aromatase inhibitors and cardiovascular problems
http://www.news-medical.net/?id=37439
New evidence has emerged that, contrary to some current fears, aromatase inhibitors (AIs) are not associated with an increased risk of heart problems in women who take them to prevent their breast cancer recurring.
Breakthrough in migraine genetics
http://www.news-medical.net/?id=37437
In a new study, published in the American Journal of Human Genetics, researchers were able for the first time to convincingly demonstrate a genomic locus to be linked to migraine susceptibility in two diverse populations.
Antipsychotic drugs increase risk of developing pneumonia in elderly
http://www.news-medical.net/?id=37410
Elderly patients who use antipsychotic drugs have a 60 percent increased risk of developing pneumonia compared to non-users.
Chemotherapy for breast cancer and problems with memory
http://www.news-medical.net/?id=37415
Women receiving chemotherapy for breast cancer frequently report problems with memory and concentration, but two new studies suggest that chemotherapy is not the cause of these problems, and the stress of the diagnosis may be.
Combining liver cancer treatments doubles survival rates
http://www.news-medical.net/?id=37417
By combining the use of stents and photodynamic therapy, also called SpyGlass, physicians at the University of Virginia have been able to significantly increase survival rates for patients suffering from advanced cholangiocarcinoma, cancer of the liver bile duct.
Two new clinical trials show promise for basal cell carcinoma and pancreatic cancer
http://www.news-medical.net/?id=37407
Clinical researchers at Scottsdale Healthcare and TGen have announced the results of two clinical trials that show promise for patients battling cancer.
Creatinine increase in elderly means increased renal disease, mortality
http://www.news-medical.net/?id=37419
Even small increases in serum creatinine levels during hospitalization raise the risk of end stage renal disease and mortality of elderly patients over the long term, according to a University of Alabama at Birmingham (UAB) study in the Archives of Internal Medicine.
Cultural identity and mental health status
http://www.news-medical.net/?id=37420
The first prospective study investigating cultural identity and mental health status among adolescents living in a culturally diverse society has revealed that there is an association between the two, and that effects differ by gender and ethnic group.
New drug for melanoma riluzole shows promise
http://www.news-medical.net/?id=37423
Rutgers Professor Suzie Chen has found that riluzole, a U.S. Food and Drug Administration (FDA) approved drug used to treat Lou Gehrig's disease (ALS), slows the growth of melanoma, the most aggressive form of malignant skin cancer.
Special asthma equipment a waste of money
http://www.news-medical.net/?id=37405
Researchers from the Cochrane Collaboration research group have reviewed 54 studies in order to assess just how well specialist asthma equipment worked; the studies involved over 3,000 people.
Health warning from Britain about vitamin supplements
http://www.news-medical.net/?id=37402
Health authorities in Britain have issued a warning regarding Vitamin supplements, they say they are probably ineffective and are possibly harmful.
Elevated levels of antioxidant urate may slow Parkinson's progression
http://www.news-medical.net/?id=37367
Naturally elevated levels of the antioxidant urate may slow the progression of Parkinson's disease in men. Researchers from the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) and Harvard School of Public Health (HSPH) examined data from an earlier study and found that, among recently diagnosed Parkinson's patients, those with the highest urate levels had a significantly slower rate of disease progression during the two-year study period.
Study details cost-effectiveness of rheumatoid arthritis treatments for Medicare recipients
http://www.news-medical.net/?id=37390
For elderly and disabled rheumatoid arthritis (RA) sufferers, the Medicare Prescription Drug Improvement and Modernization Act (MMA) brought the promise of better disease management with "biologic" drugs.
Very early photoscreening yields better visual outcomes in amblyopia treatment
http://www.news-medical.net/?id=37366
Children who screen positive for amblyopia, reduced vision in one eye, before age 2 appear to have better visual outcomes than those whose vision problems are detected during screenings between ages 2 and 4, according to a report in the April issue of Archives of Ophthalmology, one of the JAMA/Archives journals.
Blood urate levels associated with the progression of Parkinson's disease
http://www.news-medical.net/?id=37355
Higher blood levels of the compound urate, a salt derived from uric acid that is associated with gout, may be associated with a slower progression of Parkinson's disease, according to an article posted online today that will appear in the June 2008 print issue of Archives of Neurology.
Restricted-calorie diets limit development of epithelial cancers
http://www.news-medical.net/?id=37358
A restricted-calorie diet inhibited the development of precancerous growths in a two-step model of skin cancer, reducing the activation of two signaling pathways known to contribute to cancer growth and development, researchers at The University of Texas M. D. Anderson Cancer Center report today at the American Association for Cancer Research annual meeting.
Brain study may lead to improved epilepsy treatments
http://www.news-medical.net/?id=37356
Using a rodent model of epilepsy, researchers found one of the body's own neurotransmitters released during seizures, glutamate, turns on a signaling pathway in the brain that increases production of a protein that could reduce medication entry into the brain.
High blood pressure may play a role in protecting against migraine
http://www.news-medical.net/?id=37369
People with high blood pressure appear to be less likely to have migraine than those with low blood pressure.
DASH diet also may cut risk for heart disease, stroke
http://www.news-medical.net/?id=37362
Women who eat diets similar to the Dietary Approaches to Stop Hypertension (DASH) diet -which is low in animal protein, moderate in low-fat dairy products and high in plant proteins, fruits and vegetables - appear to have a lower risk of coronary heart disease and stroke, according to a report in the April 14 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Potential treatment for multiple sclerosis goes to trial
http://www.news-medical.net/?id=37381
A potential treatment for multiple sclerosis (MS), developed by University of Greenwich in association with Kings College, London, has begun clinical trials.
Regulating hematopoietic stem cell homeostasis and leukemogenesis
http://www.news-medical.net/?id=37383
In the April 15th issue of G&D, Dr. Richard Flavell (Yale University) and colleagues identify the c-Cbl protein as a critical repressor of hematopoietic stem cell (HSC) self-renewal.
Statins may modestly reduce blood pressure
http://www.news-medical.net/?id=37389
The medications known as statins, typically prescribed to lower blood cholesterol levels, may also modestly reduce blood pressure, according to a report in the April 14 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
An effective colon cancer prevention treatment
http://www.news-medical.net/?id=37397
Using a combination of a targeted cancer-fighting agent called DFMO and a low dose of an anti-inflammatory drug, UC Irvine researchers have reduced the risk of reoccurring colorectal polyps, an early sign of colon cancer, by as much as 95 percent with fewer toxic side effects.
NovoCure presents results from breast cancer pilot study
http://www.news-medical.net/?id=37379
NovoCure announced today that it presented the results from a single-arm pilot trial evaluating the Novo-TTF, a non-invasive portable medical device, combined with neo-adjuvant chemotherapy for the treatment of patients with locally advanced breast cancer.
Study shows decline in work disability due to rheumatoid arthritis
http://www.news-medical.net/?id=37392
Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the joints and, in severe cases, vital organs.
Treatment with sunitinib slows tumor growth and spread of liver cancer
http://www.news-medical.net/?id=37394
Treatment with sunitinib slows tumor growth and reduces the risk of metastasis in patients with hepatocellular carcinoma, an aggressive cancer of the liver, researchers report.
How hormone levels affect financial traders
http://www.news-medical.net/?id=37395
When City traders have high morning testosterone levels they make more than average profits for the rest of that day, researchers at the University of Cambridge have discovered.
Too many choices hinder productivity and can be mentally exhausting
http://www.news-medical.net/?id=37396
Each day, we are bombarded with options -- at the local coffee shop, at work, in stores or on the TV at home.
New insight into the pathogenesis of neurodegeneration in Ataxia telangiectasia
http://www.news-medical.net/?id=37377
An upcoming paper from Dr. David Wassarman (University of Wisconsin School of Medicine and Public Health) in the May 1 issue of G&D lends new insight into the pathogenesis of neurodegeneration in Ataxia telangiectasia.
Best use for popular CAD assessment procedure is misunderstood
http://www.news-medical.net/?id=37352
What is the best way to determine if you are developing the nation's most deadly condition, coronary artery disease (CAD)?
Statins may help control blood pressure
http://www.news-medical.net/?id=37351
Researchers in the States say that statins, the popular cholesterol-lowering drugs, may also lower blood pressure.
Traffic pollution linked to thousands of deaths from pneumonia
http://www.news-medical.net/?id=37348
British researchers are suggesting that high levels of pollution may have contributed to the deaths in recent years of thousands of people in England from pneumonia.
Curcumin or resveratrol added to conventional chemotherapy decreases survival of colon cancer cells
http://www.news-medical.net/?id=37309
Researchers from the Barbara Ann Karmanos Cancer Institute in Detroit presented findings showing that adding curcumin or resveratrol to conventional chemotherapy could be effective in preventing the growth of chemo-resistant colon cancer cells.
Medicare reimbursement changes likely influenced changes in prostate cancer treatment
http://www.news-medical.net/?id=37316
Financial pressures from Medicare reimbursement changes may have caused physicians to switch from providing hormonal-induced castration to providing surgical castration for men with prostate cancer.
The impact of obesity on U.S. economic growth
http://www.news-medical.net/?id=37319
Economists at ING Wholesale have released an in-depth/hard hitting report which attempts to model the link between obesity in the U.S. and the potential impact it might have on economic growth and the financial markets.
Researchers study Rituximab's action on cancer stem cells
http://www.news-medical.net/?id=37329
Preliminary data from one of the first clinical trials to test a stem cell-targeting drug in cancer patients shows that while the drug did not prolong survival, its suppressing effect on patients' stem cells was impressive enough to send investigators looking for a better drug to try.
Targeted therapy combo overcomes treatment resistance in liver cancer
http://www.news-medical.net/?id=37328
Researchers at the University of Pennsylvania School of Medicine and Abramson Cancer Center reported at the annual meeting of the American Association for Cancer Research that combining two targeted therapies overcomes treatment resistance in liver cancer cell lines.
What we eat and drink affects our risk of cancer
http://www.news-medical.net/?id=37306
A healthy diet and lifestyle protect against a wide range of diseases, and new research presented at the American Association for Cancer Research 2008 Annual Meeting, April 12-16, shows that cancer is no exception.
Study finds smoking related to subset of colorectal cancers
http://www.news-medical.net/?id=37315
Smoking puts older women at significant risk for loss of DNA repair proteins that are critical for defending against development of some colorectal cancers, according to research from a team led by Mayo Clinic scientists.
Cystic fibrosis, Burkholderia cenocepacia and lung transplantation
http://www.news-medical.net/?id=37312
During last Wednesday's Satellite Symposium 3: The Challenges of Lung Transplantation in Cystic Fibrosis (CF) at the International Society of Heart and Lung Transplantation (ISHLT) Annual Meeting & Scientific Sessions, clinicians and researchers discussed some of the unique challenges in achieving excellent lung transplant outcomes in patients with CF.
Increased life expectancy seen for patients with advanced cancers
http://www.news-medical.net/?id=37308
A new study indicates that patients receiving treatments for late stage testicular, colorectal and ovarian cancer have increased life expectancy, resulting from the proportion of patients cured or by prolonging survival among non-cured patients.
West Australians above the age of 69 at risk of sun-related skin cancer death
http://www.news-medical.net/?id=37324
A new Western Australian study has revealed the mortality from non-melanoma skin cancer (NMSC), commonly considered less dangerous than melanoma, is affecting older Australians at a worrying rate.
Depression in seniors
http://www.news-medical.net/?id=37326
Even after the age of 70, people prone to feelings of anxiety, worry, distress and insecurity face a risk for a first lifetime episode of clinically significant depression, according to a unique study led by a University of Rochester Medical Center researcher.
Some kids with autism may have a genetic defect that affects the muscles
http://www.news-medical.net/?id=37311
...according to research that will be presented at the American Academy of Neurology 60th Anniversary Annual Meeting in Chicago, April 12-19, 2008.
Exercise leads to significantly greater tumor growth in mouse model
http://www.news-medical.net/?id=37305
Prostate tumors grew more quickly in mice who exercised than in those who did not, leading to speculation that exercise may increase blood flow to tumors, according to a new study by researchers in the Duke Comprehensive Cancer Center (DCCC) and the Duke Prostate Center.
Low birth weight linked to heart disease
http://www.news-medical.net/?id=37341
According to new research from Britain, being small at birth along with an excessive weight gain during adolescence and young adulthood are indicators for future heart disease risk.
Newly diagnosed breast cancer patients benefit from use of USFNA of lymph nodes
http://www.news-medical.net/?id=37321
Ultrasound-guided fine needle aspiration (USFNA) of the lymph nodes is a safe, useful, and minimally invasive procedure for diagnosing metastatic disease in patients who are undergoing preoperative staging for breast cancer, according to a recent study conducted by researchers at the Rhode Island Hospital/Warren Alpert Medical School of Brown University in Providence, RI.

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