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PUTTING BREAKING MEDICAL NEWS INTO PRACTICE^™

Wednesday April 09, 2008

TODAY'S HEADLINES
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For the latest news, features, columns, video and audio reports and more, visit our home page at www.medpagetoday.com

Mixed Results with Aggressive Risk Reduction in Diabetic Patients

HYATTSVILLE, Md. -- Diabetic patients who achieved ultra-low LDL and blood pressure targets had a significant reduction in carotid intima media thickness, but no decrease in cardiovascular events, investigators here concluded. See Related Exclusive Press Conference Coverage: Merck/Schering-Plough Answer ENHANCE Critics full story

http://www.medpagetoday.com/Cardiology/Diabetes/tb/9052

Survey Is It Time to Rethink Ezetimibe?

The take-home message from the ENHANCE trial, which evaluated the ezetimibe/simvastatin combination (Vytorin), was, said one presenter at the ACC meeting, that physicians should return to evidence-based medicine, meaning more use of statins and less use of ezetimibe. Vote

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Practice Pointers

Estrogen Doubles Benign Breast Disease Risk

NEW YORK -- Postmenopausal women who took conjugated equine estrogen doubled their risk of benign proliferative breast disease, researchers here said. full story

http://www.medpagetoday.com/HematologyOncology/BreastCancer/tb/9048

Halting Trials of Cancer Drugs Early Criticized

ROME -- Stopping cancer drug trials when interim analyses show clinical benefit may actually harm patients in the long run, researchers here said. full story

http://www.medpagetoday.com/PublicHealthPolicy/ClinicalTrials/tb/9056

Combination Therapy Improves Hepatocellular Carcinoma Survival

JINAN, China -- For large hepatocellular carcinoma tumors, transarterial chemoembolization plus radiofrequency ablation improves survival better than either alone, according to researchers here. full story

http://www.medpagetoday.com/Radiology/TherapeuticRadiology/tb/9055

FDA Increases Death Count Associated with Tainted Heparin to 62
ROCKVILLE, Md. -- The FDA said today there have been 62 fatal allergic reactions following the use of apparently adulterated heparin, and 56 of the deaths were reported since the agency drew attention to the problem at the first of the year. full story

http://www.medpagetoday.com/ProductAlert/Prescriptions/tb/9054

EXCLUSIVE PRESS CONFERENCE COVERAGE: Merck/Schering-Plough Answer ENHANCE Critics

CHICAGO -- In this exclusive MedPage Today video, recorded here on March 30 while the American College of Cardiology was meeting and aired now for the first time, Merck/Schering-Plough executives and researchers defend the efficacy of lipid-lowering with ezetimibe/simvastatin (Vytorin). full story

http://www.medpagetoday.com/MultiMedia/MultiMedia/tb/9051

Left Atrial Isolation Improves Results with Arrhythmia Surgery

ST. LOUIS -- For atrial fibrillation patients, the effective but complicated Cox maze procedure has been enhanced by a step that takes only a few seconds to perform, according to investigators here. full story

http://www.medpagetoday.com/Cardiology/Arrhythmias/tb/9053

Special Report: Less Weight, More Energy Two Months into Weight Loss Trial

CHICAGO -- I’m on an eight-week losing streak. And that’s a good thing. Two months into my participation in a clinical trial testing an investigational diet drug, I’ve lost 16 pounds -- and a lot of hair. full story

http://www.medpagetoday.com/Pediatrics/PreventiveCare/tb/9045

Parenting Behavior Plays a Part in Preschoolers’ Sleep Problems

MONTREAL -- Sleep problems in preschoolers may be partly the result of disturbances earlier in childhood and how parents respond to them, a longitudinal study revealed. full story

http://www.medpagetoday.com/Pediatrics/GeneralPediatrics/tb/9049

Gymnasts Face Same Risk of Injury as Hockey Players

COLUMBUS, Ohio -- Gymnastics has one of the highest injury rates of all girls’ sports, investigators here have found. full story

http://www.medpagetoday.com/PrimaryCare/ExerciseFitness/tb/9037

EB: OTC Painkillers Also Help Grandpa Get Buff

SAN DIEGO -- Over-the-counter painkillers may promote muscle growth in older patients during weight training, a randomized, placebo-controlled study showed. full story

http://www.medpagetoday.com/Geriatrics/GeneralGeriatrics/tb/9044

Drug Errors No Stranger to Pediatric Units of Hospitals

LOS ANGELES -- Hospitalized children are commonly given the wrong drug or an erroneous dose, researchers here reported. full story

http://www.medpagetoday.com/PublicHealthPolicy/PublicHealth/tb/9043

CME SPOTLIGHT

Controversies and Consensus in the Management of HIV: Interactive Debates
Are NNRTI- or PI-based regimens the best choice for initial ARV therapy? If a patient is failing therapy, when should you switch? Do treatment experienced patients require 2 or 3 active ARV agents? Join us for thoughtful debates and lively discussion led by a panel of HIV experts.
Source: AdvancMed [more]

Evolution in the Use of Boosted PIs as First-line Therapy: Factors to Consider
Drs Graeme Moyle and Sharon Walmsley review studies that compare efficacy, safety, and metabolic parameters of PIs in head-to-head trials along with emerging data on drug-drug interactions and insulin resistance.
Source: AdvancMed [more]

Emerging Trends in the Treatment of Renal Cell Carcinoma
Drs. Michael B. Atkins, Bernard J. Escudier, and Gary R. Hudes lead this CME activity which examines current and evolving standards of care for the treatment of early stage and advanced renal cell carcinoma; best practices for optimal patient outcomes are also covered.
Source: The Physicians Academy For Clinical and Management Excellence [more]

Medical and Surgical Management of Aortic Valve Disease
Join Dr. Joseph E. Bavaria, MD and the team of University of Pennsylvania cardiology and surgery specialists in reviewing of all the important topics related to aortic valve conditions that a cardiovascular clinician faces on a daily basis.
Source: University of Pennsylvania School of Medicine [more]

MRI Evaluation of the Contralateral Breast in Women with Recently Diagnosed Breast Cancer
In this free CME/CE/CPE article review, William J. Gradishar, MD, discusses how early use of MRI in women with recently diagnosed unilateral breast cancer can improve detection of tumors in the contralateral breast.
Source: Projects In Knowledge [more]

Managing the Symptomatic Menopausal Patient in Primary Care: A Case-Based Approach
This interactive CME activity provides practical recommendations and the latest clinical evidence to improve the personalized care a women receives during menopause.
Source: Interstate Postgraduate Medical Association and MEV Healthcom, Inc. [more]

JOURNAL DOWNLOADS

First-line SUTENT® data recently published in NEJM
Read first-line SUTENT data in the New England Journal of Medicine. Get it at SUTENThcp.com Source: Pfizer [more]

RESOURCES

Now Approved: A new development in the treatment of hypertension.
Now approved from Forest Laboratories: Bystolic (nebivolol). A novel beta blocker for the treatment of hypertension. Click here to learn more. Source: Forest Labs [more]

Explore the Possibilities in Type 2 Diabetes.
View efficacy studies: Type 2 diabetes efficacy research & 18 and 24-week study designs. Source: Merck [more]

Access information on more than 150 Pfizer products at PfizerPro.com
Pfizer medicines have a new home on the Web. Visit PfizerPro.com for information on more than 150 Pfizer products. Convenient access to full prescribing information, scientific literature, professional resources, patient education material, and more. Source: Pfizer [more]

Take a closer look at all 3 major lipids and cardiovascular risk. HDL, LDL and TG levels may be independently associated with cardiovascular risk.
Visit www.totallipids.com, a new source of information for health care professionals, about dyslipidemia, all 3 lipids, and cardiovascular risk. Source: Merck [more]

Featured Job Opportunities from MedJobs Today

Urology, Arkansas
Position consists of clinic, hospital consults, and surgery, and there is ER coverage with a minimum of 10 days per month.
http://www.medjobstoday.com/seeker/job_detail.cfm?jobid=17311&refsrc=dh
Urology, New York
A teaching facility in upstate New York is seeking two urologists to place for clinic and call coverage.
http://www.medjobstoday.com/seeker/job_detail.cfm?jobid=17590&refsrc=dh
Urology, Wisconsin
This opening is for weekend call coverage from Friday evening at 5pm to Monday morning at 8am.
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Visit MedJobs Today.com to search for a new job!

CROI Meeting

CROI: Atazanavir Equals Lopinavir in Head-On Contest

CROI: Extended HIV Treatment for Babies Reduces Breast-Milk Risk

SABCS Meeting

SABCS: Optimizing Breast Cancer Treatment with Biologics

SABCS: A Call to Scrap Anthracyclines for Breast Cancer

ACG Meeting

ACG: Weight Gain with Infliximab in Crohn's Disease Confirmed but Not Explained

ACG: Natalizumab Demonstrates Activity in Crohn's Disease After
Anti-TNF Failure

AHA Meeting

AHA: Step Care Hypertension Algorithm Gets Patients to Goals

AHA: Women Have More Complications than Men with ICD Implants

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