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PUTTING BREAKING MEDICAL NEWS INTO PRACTICE^™

Thursday April 17, 2008

TODAY'S HEADLINES
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Did you know that you can earn CME/CE credit by reading our news reports? Look for the CME designation after the article title.

Researchers Debate Ezetimibe/Simvastatin (Vytorin) ENHANCE Trial

Controversy over the ENHANCE trial continued despite lengthy presentations at the American College of Cardiology meeting earlier this month. In this exclusive video report MedPage Today talks in-depth with two researchers about ezetimibe, LDL, and clinical implications of the trial. Part 2: Trial Design Part 3: Clinical Implications full story

http://www.medpagetoday.com/Cardiology/Dyslipidemia/tb/9111

AAN: Pork Worker Nerve Illness Has Autoimmune Cause

CHICAGO -- An autoimmune reaction stemming from exposure to aerosolized pig brains appears to have caused mysterious neurological symptoms in some two dozen Midwestern pork plant workers, researchers said here. full story

http://www.medpagetoday.com/MeetingCoverage/AANMeeting/tb/9147

Supplier Denies Economics at Root of Heparin Contamination
WASHINGTON -- The supplier of the crude heparin that is the focus of an FDA investigation has denied that profit was the motive for contamination of heparin. full story

http://www.medpagetoday.com/Nephrology/ESRD/tb/9146

Weekly Paclitaxel (Taxol) Improves Survival in Breast Cancer Chemotherapy

NEW YORK -- Weekly paclitaxel (Taxol) outdid docetaxel (Taxotere) every week or every three weeks in disease-free and overall survival for women with axillary lymph node or high-risk node-negative breast cancer, researchers here reported. full story

http://www.medpagetoday.com/HematologyOncology/BreastCancer/tb/9145

AACR: Prenatal Folate Reduces Colon Cancer Risk in Preclinical Model

SAN DIEGO -- Folate supplementation during pregnancy may reduce the offspring’s subsequent risk of colon cancer, data from a preclinical model suggest. full story

http://www.medpagetoday.com/MeetingCoverage/AACRMeeting/tb/9140

Racial Difference in Kidney Disease Remains Mystery

SAN FRANCISCO, April 16 -- A long-accepted explanation of racial differences in kidney disease -- that higher creatinine levels arise from greater muscle mass -- turns out to likely be false, researchers here said. full story

http://www.medpagetoday.com/Nephrology/ESRD/tb/9144

Seasonal Flu Starts in Asia and Migrates Throughout World

CAMBRIDGE, England -- Seasonal influenza starts in east and southeast Asia and follows a highly predictable path to infect the rest of the world, researchers here said. full story

http://www.medpagetoday.com/InfectiousDisease/URItheFlu/tb/9142

Some Biologics Are More Cost-Effective than Others in RA

SHEFFIELD, England -- For treatment of Medicare patients with rheumatoid arthritis, etanercept (Enbrel) and adalimumab (Humira) appear to be more cost-effective than infliximab (Remicade) or anakinra (Kineret), an analysis showed. full story

http://www.medpagetoday.com/Rheumatology/Arthritis/tb/9141

Dopamine Agonist Risk-Benefit Unclear in Parkinson’s

BIRMINGHAM, England -- Despite some drawbacks with dopamine agonists, they seem better at controlling motor complications of early Parkinson’s disease than levodopa, researchers here found in a meta-analysis. full story

http://www.medpagetoday.com/Neurology/ParkinsonsDisease/tb/9139

Researchers Debate Ezetimibe/Simvastatin (Vytorin) ENHANCE Trial

Controversy over the ENHANCE trial continued despite lengthy presentations at the American College of Cardiology meeting earlier this month. In this exclusive video report MedPage Today talks in-depth with two researchers about ezetimibe, LDL, and clinical implications of the trial. Part 1: Mechanism of Action Part 3: Clinical Implications full story

http://www.medpagetoday.com/Cardiology/Dyslipidemia/tb/9122

Researchers Debate Ezetimibe/Simvastatin (Vytorin) ENHANCE Trial

Controversy over the ENHANCE trial continued despite lengthy presentations at the American College of Cardiology meeting earlier this month. In this exclusive video report MedPage Today talks in-depth with two researchers about ezetimibe, LDL, and clinical implications of the trial. Part 1: Mechanism of Action Part 2: Trial Design full story

http://www.medpagetoday.com/Cardiology/Dyslipidemia/tb/9124

AAN: Promising Long-Term Results for Oral MS Drug

CHICAGO -- Early reductions in multiple sclerosis relapse rate seen with the investigational oral drug fingolimod may be sustained long term, researchers reported here. full story

http://www.medpagetoday.com/MeetingCoverage/AANMeeting/tb/9138

AAN: High-Dose Vitamin E May Help Alzheimer Patients

CHICAGO -- High-dose vitamin E supplements do not worsen outcomes in patients with Alzheimer’s disease and may help, researchers said here. full story

http://www.medpagetoday.com/MeetingCoverage/AANMeeting/tb/9134

CME SPOTLIGHT

Managing CardioMetabolic Complexities
You are invited to participate in the following free educational activity where you will learn about the interrelated factors contributing to the metabolic syndrome and novel therapeutic strategies aimed at attenuating cardiometabolic risk while delaying disease progression.
Source: SciMed New York [more]

The Quest for Erythropoiesis: A Preoperative Red Blood Cell Production
This Web activity, featuring experts in the field of blood management, provides a data-driven approach to the preoperative management of anemia in patients undergoing elective surgery.
Source: AdvancMed [more]

Taking the Path of Least Resistance to Improved Clinical Outcomes from Surgical Site Infections
Join Dr. Sawyer for an innovative and in-depth CME-certified Activity on taking the path of least resistance to improve clinical outcomes from surgical site infections.
Source: CME Enterprise [more]

Managing the Symptomatic Menopausal Patient in Primary Care: A Case-Based Approach
This interactive CME activity provides practical recommendations and the latest clinical evidence to improve the personalized care a women receives during menopause.
Source: Interstate Postgraduate Medical Association and MEV Healthcom, Inc. [more]

Emerging Trends in the Treatment of Renal Cell Carcinoma
Drs. Michael B. Atkins, Bernard J. Escudier, and Gary R. Hudes lead this CME activity which examines current and evolving standards of care for the treatment of early stage and advanced renal cell carcinoma; best practices for optimal patient outcomes are also covered.
Source: The Physicians Academy For Clinical and Management Excellence [more]

Medical and Surgical Management of Aortic Valve Disease
Join Dr. Joseph E. Bavaria, MD and the team of University of Pennsylvania cardiology and surgery specialists in reviewing of all the important topics related to aortic valve conditions that a cardiovascular clinician faces on a daily basis.
Source: University of Pennsylvania School of Medicine [more]

The Evolution and Role of Incretin-Based Therapeutics.
This activity reviews the pathogenesis of type 2 diabetes, the mechanisms by which incretin hormones affect glucose homeostasis, and the role of incretin-based therapeutics in the management of type 2 diabetes.
Source: SciMed New York [more]

New phase 3 trials may dramatically alter the management of newly diagnosed myeloma.
This activity reviews these trials as well as new developments in transplantation and relapsed/refractory therapies.
Source: Curatio CME Institute [more]

JOURNAL DOWNLOADS

Efficacy Data for CTCL Published in JCO
Efficacy Data for CTCL Published in JCO. Source: Merck. [more]

First-line SUTENT� data recently published in NEJM
Read first-line SUTENT data in the New England Journal of Medicine. Get it at SUTENThcp.com Source: Pfizer [more]

RESOURCES

Access information on more than 150 Pfizer products at PfizerPro.com
Pfizer medicines have a new home on the Web. Visit PfizerPro.com for information on more than 150 Pfizer products. Convenient access to full prescribing information, scientific literature, professional resources, patient education material, and more. Source: Pfizer [more]

Find comprehensive, up-to-date information about clinical trials in oncology with TrialTrove?
Visit www.rocheexchange.com to access TrialTrove™, a real-time global oncology clinical trials database. For your convenience, each trial summary describes the study design, inclusion and exclusion criteria, and where the research is being conducted. [more]

Frequently painful. Potentially severe. Learn why your patients maybe be at risk.
Zoster: How Many of your patients are at risk? Source: Merck [more]

Take a closer look at all 3 major lipids and cardiovascular risk. HDL, LDL and TG levels may be independently associated with cardiovascular risk.
Visit www.totallipds.com, a new source of information for health care professionals, about dyslipidemia, all 3 lipids, and cardiovascular risk. Source: Merck [more]

Preventive migraine therapy with a proven safety profile
Looking for a different treatment option for migraine patients? Consider the #1 medication prescribed by neurologists for migraine prevention1. Click to learn more about a treatment option with a proven safety profile. 1.IMS Health January 2008 . Source: Ortho-McNeil Neurologics [more]

Featured Job Opportunities from MedJobs Today

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Position consists of clinic, hospital consults, and surgery, and there is ER coverage with a minimum of 10 days per month.
http://www.medjobstoday.com/seeker/job_detail.cfm?jobid=17311&refsrc=dh
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A teaching facility in upstate New York is seeking two urologists to place for clinic and call coverage.
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Is This a Job for Congress?
Rep. John D. Dingell (D-Mich.), chairman of the House Committee on Energy and Commerce, and Rep. Bart Stupak (D-Mich.), chairman of the Oversight and Investigations Subcommittee, are in the midst of a months-long investigation of the way Merck and Schering-Plough have handled the ENHANCE data. Vote

DDW Meeting

DDW: Contrary to Common Wisdom, Statins May Offer Liver Benefit

DDW: IBS And Restless Legs Syndrome Linked

AAPA Meeting

AAPA: Year-in-Review, Newly Approved Drugs

AANP Meeting

AANP: Pain May Be a Major Factor for Sleep Disturbances in Diabetes

ASCO Meeting

ASCO: No NSCLC Survival Benefit with Neoadjuvant Chemotherapy

Get tools, resources & information about Gleevec matching the experience of attendees of the 2007 ASH Annual Meeting.

Did you miss the Gleevec booth at the 2007 ASH Meeting? Get tools, resources and information about Gleevec via a fully interactive virtual exhibit booth, matching the experience of attendees of the 2007 ASH Annual Meeting.

Source: Novartis Oncology.

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