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PUTTING BREAKING MEDICAL NEWS INTO PRACTICE^™

Monday April 21, 2008

TODAY'S HEADLINES
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For the latest news, features, columns, video and audio reports and more, visit our home page at www.medpagetoday.com

AACR: Intraductal Drug Delivery Evaluated for Breast Cancer

SAN DIEGO -- Chemotherapy through the nipple may have potential as a treatment for ductal carcinoma in situ and possibly breast cancer prevention, according to a feasibility study. full story

http://www.medpagetoday.com/MeetingCoverage/AACRMeeting/tb/9167

EBBC: Aromatase Inhibitors Do Not Increase Cardiovascular Risks

BERLIN -- In postmenopausal women with breast cancer, adjuvant treatment with aromatase inhibitors does not raise the risk for cardiovascular events, a researcher said. full story

http://www.medpagetoday.com/MeetingCoverage/AdditionalMeetings/tb/9180

Reasons for Decline in Prostate Cancer Mortality Not Clear

BRISTOL, England -- Mortality rates from prostate cancer have declined far more rapidly in the U.S. than in Britain, but the role of differences in screening rates and types of treatment remains unclear, researchers said. full story

http://www.medpagetoday.com/HematologyOncology/ProstateCancer/tb/9179

AAN: Glatiramer Delays Early Multiple Sclerosis Progression

CHICAGO -- Glatiramer acetate (Copaxone) delayed the onset of clinically confirmed multiple sclerosis by more than a year in patients with early signs of the disease, a researcher said here. full story

http://www.medpagetoday.com/MeetingCoverage/AANMeeting/tb/9178

AAN: Investigational Amyloid Inhibitor Slows Early Alzheimer’s Progression

CHICAGO -- Progression of early Alzheimer’s disease was significantly delayed with an oral investigational agent that blocks rogue beta-amyloid protein, a researcher said here. full story

http://www.medpagetoday.com/MeetingCoverage/AANMeeting/tb/9166

Modified Psoriasis Drug Safe and Effective

WATERLOO, Ontario -- An investigational compound for chronic plaque psoriasis is safe and effective, researchers here said. full story

http://www.medpagetoday.com/Dermatology/Psoriasis/tb/9172

AACR: Colon Cancer Prevention Continues after Stopping Celecoxib (Celebrex)

SAN DIEGO -- Apparent colon cancer-preventing effects of celecoxib (Celebrex) persist for at least five years, including two years after halting therapy, according to a long-term follow-up of high-risk patients in a trial. full story

http://www.medpagetoday.com/MeetingCoverage/AACRMeeting/tb/9150

Podcast: Alzheimer’s Disease Vaccine Trial Suspended on Safety Concern

CHICAGO -- In this exclusive MedPage Today podcast, Jeffrey Cummings, M.D., of the University of California Los Angeles, discusses the suspension of a clinical trial for the investigational Alzheimer’s disease vaccine ACC-001. full story

http://www.medpagetoday.com/MeetingCoverage/AANMeeting/tb/9165

AAN: Common Anticholinergics Speed Cognitive Decline

CHICAGO -- Older patients who start anticholinergic drugs for bladder control or other purposes may find themselves losing their mental edge, researchers found. full story

http://www.medpagetoday.com/MeetingCoverage/AANMeeting/tb/9151

AACR: Statin-COX2 Inhibitor Combo Slows Prostate Cancer Growth

SAN DIEGO -- Progression of androgen-independent prostate cancer was significantly inhibited in mice by a combination of atorvastatin (Lipitor) and celecoxib (Celebrex), according to a study reported here. full story

http://www.medpagetoday.com/MeetingCoverage/AACRMeeting/tb/9148

AAN: Pediatric Headache Type Linked to Troubled Sleep

CHICAGO -- The nature of children’s headaches may be linked to their particular sleep disorders, researchers reported here. full story

http://www.medpagetoday.com/MeetingCoverage/AANMeeting/tb/9170

Statins May Take Blood Pressure Down a Notch

SAN DIEGO -- Besides lowering cholesterol, statins may have a similar, if modest, effect on blood pressure, a randomized trial found. full story

http://www.medpagetoday.com/Cardiology/Hypertension/tb/9169

CME SPOTLIGHT

neuroscienceCME Journal Club
Trouble keeping up with the latest findings from the clinical literature? neuroscienceCME Journal Club can help. Hear leading authors talk about just-published articles, and then answer your questions. Hosted by Thomas Roth, PhD.
Source: CME Outfitters [more]

Impact of ADHD and Its Treatment on Substance Abuse
Join Dr. Timothy Wilens in an in-depth CME activity as he discusses emerging data on the impact of ADHD and its treatment on substance use disorder, especially as related to adolescents and adults.
Source: The Physicians Academy For Clinical and Management Excellence [more]

Bridging Cultural Differences to Improve HBV Treatment in Asian and Other Diverse Communities
This CME/CE program features state-of-the-science information on hepatitis B virus (HBV) disease burden, HBV replication and transmission, screening for HBV, treatment options and management of HBV.
Source: Projects In Knowledge [more]

Managing the Symptomatic Menopausal Patient in Primary Care: A Case-Based Approach
This interactive CME activity provides practical recommendations and the latest clinical evidence to improve the personalized care a women receives during menopause.
Source: Interstate Postgraduate Medical Association and MEV Healthcom, Inc. [more]

Genital HPV and HPV Vaccines: Winning acceptance among adolescents and their parents
HPV is a highly prevalent sexually transmitted infection, most common in sexually active women under the age of 25. The following free educational activity is designed to educate physicians about the most common types of genital HPV and review the safety and efficacy of utilizing HPV vaccines.
Source: SciMed New York [more]

The Evolution and Role of Incretin-Based Therapeutics.
This activity reviews the pathogenesis of type 2 diabetes, the mechanisms by which incretin hormones affect glucose homeostasis, and the role of incretin-based therapeutics in the management of type 2 diabetes.
Source: SciMed New York [more]

Evolution in the Use of Boosted PIs as First-line Therapy: Factors to Consider
Drs Graeme Moyle and Sharon Walmsley review studies that compare efficacy, safety, and metabolic parameters of PIs in head-to-head trials along with emerging data on drug-drug interactions and insulin resistance.
Source: AdvancMed [more]

JOURNAL DOWNLOADS

Efficacy Data for CTCL Published in JCO
Efficacy Data for CTCL Published in JCO. Source: Merck. [more]

RESOURCES

Find comprehensive, up-to-date information about clinical trials in oncology with TrialTrove™
Visit www.rocheexchange.com to access TrialTrove™, a real-time global oncology clinical trials database. For your convenience, each trial summary describes the study design, inclusion and exclusion criteria, and where the research is being conducted. Source: Roche [more]

Learn how Starlix® helps control mealtime glucose surges in patients with Type 2 Diabetes
View this e-learning for the latest information on Starlix and order valuable resources including samples and patient education materials. Source: Novartis [more]

Take a closer look at all 3 major lipids and cardiovascular risk. HDL, LDL and TG levels may be independently associated with cardiovascular risk.
Visit www.totallipds.com, a new source of information for health care professionals, about dyslipidemia, all 3 lipids, and cardiovascular risk. Source: Merck [more]

Preventive migraine therapy with a proven safety profile
Looking for a different treatment option for migraine patients? Consider the #1 medication prescribed by neurologists for migraine prevention1. Click to learn more about a treatment option with a proven safety profile. 1.IMS Health January 2008 . Source: Ortho-McNeil Neurologics [more]

Featured Job Opportunities from MedJobs Today

Urology, Arkansas
Position consists of clinic, hospital consults, and surgery, and there is ER coverage with a minimum of 10 days per month.
http://www.medjobstoday.com/seeker/job_detail.cfm?jobid=17311&refsrc=dh
Urology, New York
A teaching facility in upstate New York is seeking two urologists to place for clinic and call coverage.
http://www.medjobstoday.com/seeker/job_detail.cfm?jobid=17590&refsrc=dh
Urology, Wisconsin
This opening is for weekend call coverage from Friday evening at 5pm to Monday morning at 8am.
http://www.medjobstoday.com/seeker/job_detail.cfm?jobid=17779&refsrc=dh

Visit MedJobs Today.com to search for a new job!

Is This a Job for Congress?
Rep. John D. Dingell (D-Mich.), chairman of the House Committee on Energy and Commerce, and Rep. Bart Stupak (D-Mich.), chairman of the Oversight and Investigations Subcommittee, are in the midst of a months-long investigation of the way Merck and Schering-Plough have handled the ENHANCE data. Vote

DDW Meeting

DDW: Contrary to Common Wisdom, Statins May Offer Liver Benefit

DDW: IBS And Restless Legs Syndrome Linked

AAPA Meeting

AAPA: Year-in-Review, Newly Approved Drugs

AANP Meeting

AANP: Pain May Be a Major Factor for Sleep Disturbances in Diabetes

ASCO Meeting

ASCO: No NSCLC Survival Benefit with Neoadjuvant Chemotherapy

Get tools, resources & information about Gleevec matching the experience of attendees of the 2007 ASH Annual Meeting.

Did you miss the Gleevec booth at the 2007 ASH Meeting? Get tools, resources and information about Gleevec via a fully interactive virtual exhibit booth, matching the experience of attendees of the 2007 ASH Annual Meeting.

Source: Novartis Oncology.

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