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NEW YORK -- The commonly used epilepsy drug phenytoin (Dilantin, Phenytek) may cause significant bone loss for women in as little as a year, researchers found. full story

http://www.medpagetoday.com/Neurology/Seizures/tb/9222

Survey Is ECG a Plus Before ADHD Therapy?

The American Heart Association has said it’s reasonable to do a baseline ECG before starting children on stimulant therapy for ADHD. Vote

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Excess Mortality Seen with Hemoglobin-Based Blood Substitutes

BETHESDA, Md. -- Hemoglobin-based blood substitutes are too risky for additional clinical trials, according to investigators here. full story

http://www.medpagetoday.com/EmergencyMedicine/EmergencyMedicine/tb/9263

Tight Blood Pressure Control Fails to Stall Kidney Disease in Blacks

BALTIMORE -- Many African Americans getting tight blood pressure control had worsening chronic kidney disease nonetheless, a large multicenter trial found. full story

http://www.medpagetoday.com/Nephrology/Hypertension/tb/9262

Hormone Therapy Linked to Stroke Regardless of Timing

BOSTON -- Women on hormone therapy are at increased risk of stroke, whether they start shortly before or a decade after menopause, researchers here said. full story

http://www.medpagetoday.com/Geriatrics/Strokes/tb/9261

Blocking T-Cell Protein Slows HIV Activity

BETHESDA, Md. -- Blocking a protein that regulates the activity of immune cells appears to make it harder for HIV to infect them efficiently, researchers here said. full story

http://www.medpagetoday.com/HIVAIDS/HIVAIDS/tb/9253

Osteoporosis Drug Elevates Atrial Fibrillation Risk

SEATTLE -- Women taking the bisphosphonate alendronate (Fosamax) for osteoporosis may have almost double the risk of atrial fibrillation, even after they stop taking the drug, researchers found. full story

http://www.medpagetoday.com/Endocrinology/Osteoporosis/tb/9260

AANS: Brain Pacemaker Effective in Resistant Depression

CHICAGO -- Investigational deep-brain stimulation gave year-long relief from severe depression in half of patients in a small study who had been refractory to multiple conventional therapies, a researcher said here. full story

http://www.medpagetoday.com/Psychiatry/Depression/tb/9257

Gene Therapy Shows Promise for Blindness Reversal

PHILADELPHIA -- Gene therapy for blindness caused by Leber’s congenital amaurosis led to improved vision for four of the first six patients treated, including all three at a hospital here. full story

http://www.medpagetoday.com/Ophthalmology/GeneralOphthalmology/tb/9258

ASA: NCI-Designated Hospitals Have Lower Mortality after Colorectal Surgery

NEW YORK -- When colorectal cancer surgery is done at National Cancer Institute-designated centers, patients have half the postoperative mortality risk of those with similar procedures elsewhere, researchers reported here. full story

http://www.medpagetoday.com/Gastroenterology/ColonCancer/tb/9252

AANS: Weight-Loss Surgery Improves Back Pain

CHICAGO -- Substantial weight loss from bariatric surgery may relieve back pain, reduce disability, and improve quality of life, researchers reported here. full story

http://www.medpagetoday.com/PainManagement/BackPain/tb/9243

Type 2 Diabetes a Growing Problem in Pregnancy

PASADENA, Calif. -- The rising rate of type 2 diabetes in young adults is spilling over into pregnancy, a concern that is competing with that of gestational diabetes, researchers found. full story

http://www.medpagetoday.com/Endocrinology/Diabetes/tb/9212

ASA: Robotic CABG Paints Cost-Effective Benefits for Patients

NEW YORK -- Coronary artery bypass graft surgery done with the DaVinci robot shortened hospital stays and improved major cardiovascular event rates compared with standard open CABG, researchers reported here. full story

http://www.medpagetoday.com/Cardiology/CoronaryArteryDisease/tb/9254

CME SPOTLIGHT

Emerging Patient Challenges in COPD: Interactive Case Simulator
Designed for primary care clinicians. This case-based CME activity provides a virtual learning experience, allowing participants to order diagnostic tests, prescribe drugs, diagnose and develop new treatment strategies; simulating clinical practice.
Source: CASIVUS [more]

Targeted Cancer Therapy From Trial To Clinic
Join Drs. Balducci, Atkins, Cantley, and Herbst for an innovative and in-depth CME-certified Activity on how integration of targeted and conventional therapies for treating cancer is improving patient outcomes.
Source: The Physicians Academy For Clinical and Management Excellence [more]

Emerging Trends in the Treatment of Renal Cell Carcinoma
Drs. Michael B. Atkins, Bernard J. Escudier, and Gary R. Hudes lead this CME activity which examines current and evolving standards of care for the treatment of early stage and advanced renal cell carcinoma; best practices for optimal patient outcomes are also covered.
Source: The Physicians Academy For Clinical and Management Excellence [more]

Case Study: Targeted Adjuvant Therapy for HER2-Positive Breast Cancer
Free CME/CE/CPE case-based newsletter. Harold J. Burstein, MD, PhD, considers treatment options for a patient with HER2-positive invasive breast cancer and describes how patient age, medical history, and HER2 status can be used to predict prognosis and aid in selecting an appropriate targeted therapy.
Source: Projects In Knowledge [more]

Medical and Surgical Management of Aortic Valve Disease
Join Dr. Joseph E. Bavaria, MD and the team of University of Pennsylvania cardiology and surgery specialists in reviewing of all the important topics related to aortic valve conditions that a cardiovascular clinician faces on a daily basis.
Source: University of Pennsylvania School of Medicine [more]

Myeloma Landscape 2008: Highlights in Frontline Therapy, Transplantation, and Relapsed/Refractory Disease.
This activity reviews these trials as well as new developments in transplantation and relapsed/refractory therapies.
Source: Curatio CME Institute [more]

The Evolution and Role of Incretin-Based Therapeutics.
This activity reviews the pathogenesis of type 2 diabetes, the mechanisms by which incretin hormones affect glucose homeostasis, and the role of incretin-based therapeutics in the management of type 2 diabetes.
Source: SciMed New York [more]

Evolution in the Use of Boosted PIs as First-line Therapy: Factors to Consider
Drs Graeme Moyle and Sharon Walmsley review studies that compare efficacy, safety, and metabolic parameters of PIs in head-to-head trials along with emerging data on drug-drug interactions and insulin resistance.
Source: AdvancMed [more]

RESOURCES

Review safety, efficacy and PIs for Pfizer oncology medicines; search clinical trials, review pipeline, and more
Visit PfizerOncology.com to access the latest reprints, slides, and other resources, organized by tumor type; efficacy, safety, and dosing for Pfizer oncology drugs; current oncology news; clinical trials suitable for your patients; and more. Source: Pfizer [more]

Frequently painful. Potentially severe. Learn why your patients maybe be at risk.
Zoster: How Many of your patients are at risk? Source: Merck [more]

Find comprehensive, up-to-date information about clinical trials in oncology with TrialTrove™
Visit www.rocheexchange.com to access TrialTrove™, a real-time global oncology clinical trials database. For your convenience, each trial summary describes the study design, inclusion and exclusion criteria, and where the research is being conducted. Source: Roche [more]

Learn how Starlix® helps control mealtime glucose surges in patients with Type 2 Diabetes
View this e-learning for the latest information on Starlix and order valuable resources including samples and patient education materials. Source: Novartis [more]

View product information to discover more about sequential therapy in early breast cancer
Efficacy ? Safety ? Dosing ? Key reprints ? Materials and tools ? Easy-to-read prescribing information ? Patient educational materials Source: Pfizer [more]

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