TODAY'S HEADLINES
Add us to your address book or trusted sender list to help ensure delivery.

For the latest news, features, columns, video and audio reports and more, visit our home page at www.medpagetoday.com

APA: PTSD May Be Major Combat Scar of Iraq Vets

WASHINGTON -- Some 1.6 million men and women have served in Iraq and Afghanistan -- and 300,000 of them are likely to develop posttraumatic stress disorder, said researchers captured in an exclusive video at the American Psychiatric Association meeting. full story

http://www.medpagetoday.com/MeetingCoverage/APA/tb/9368

http://broadcaster.medpagetoday.com/t?r=2&c=1670&l=15&ctl=AE19:9838B2B174207BC4D84C64752B53A9AC

AGS: A Little Anticholinergic Burden Can Be Disabling

WASHINGTON -- Drugs not usually thought of as anticholinergics -- such as furosemide (Lasix) and diltiazem (Cardizem) -- could lead to functional impairment when taken in combination, researchers reported here. full story

http://www.medpagetoday.com/MeetingCoverage/AGS/tb/9367

B Vitamins Have No Effect on Cardiovascular Risk in Women

BOSTON -- Long-term supplementation with B vitamins and folic acid did not lower the risk of cardiovascular events in women, a randomized, controlled trial showed. full story

http://www.medpagetoday.com/Cardiology/Prevention/tb/9366

APA: Narcolepsy Drug Seems to Limit Olanzapine Weight Gain

WASHINGTON -- The narcolepsy agent modafinil (Provigil) significantly reduced the weight gain associated with the antipsychotic drug olanzapine (Zyprexa), according to a small pilot trial reported here. full story

http://www.medpagetoday.com/MeetingCoverage/APA/tb/9364

Low Vitamin D Linked to Depression in Older Adults

AMSTERDAM -- Depression in older adults may be related to poor vitamin D status and elevated parathyroid hormone levels, researchers here said. full story

http://www.medpagetoday.com/Psychiatry/Depression/tb/9362

Group B Streptococcus Rates Rise in Adults, Fall in Infants

ATLANTA -- Early onset group B streptococcal disease rates fell with revision of prevention guidelines but these improvements were more than offset by a substantial increase among adults, CDC surveillance found. full story

http://www.medpagetoday.com/InfectiousDisease/GeneralInfectiousDisease/tb/9360

PAS: Infant Development a Mystery to Some Parents

HONOLULU -- Infants are distressingly mystifying to many parents, found investigators here. full story

http://www.medpagetoday.com/MeetingCoverage/PAS/tb/9357

NSAID Use Linked to Reduced Alzheimer’s Risk

BOSTON -- The risk of Alzheimer’s disease decreased significantly with long-term use of nonsteroidal anti-inflammatory drugs, particularly ibuprofen, according to findings from a large observational study. full story

http://www.medpagetoday.com/Geriatrics/AlzheimersDisease/tb/9356

APA: Depressed Inpatients May Benefit from Drug-Metabolizing Enzyme Testing

WASHINGTON -- Testing depressed inpatients for abnormalities in cytochrome P450 drug-metabolizing enzymes may be warranted, a researcher said here. full story

http://www.medpagetoday.com/MeetingCoverage/APA/tb/9355

APA: Teen Angst May Sow Seeds of Psychosis

WASHINGTON -- The angst of adolescence, especially if accompanied by many symptoms, may be a precursor to schizophrenia and other psychoses, a researcher said here. full story

http://www.medpagetoday.com/MeetingCoverage/APA/tb/9352

Guidelines Call Botulinum Toxin Ineffective for Headache

NEW YORK -- Botulinum toxin injections (Botox, Myobloc) should be shunned for relief of episodic migraine and chronic tension headaches, according to guidelines just issued by the American Academy of Neurology. full story

http://www.medpagetoday.com/PainManagement/Migraines/tb/9339

APA: Deep Brain Stimulation Lifts Depression in Multicenter Trial

WASHINGTON -- Deep brain stimulation relieved depression in 56% of patients treated in a multicenter Canadian trial. full story

http://www.medpagetoday.com/MeetingCoverage/APA/tb/9351

APA: Schneiderian Symptoms Worse in Schizophrenia Patients but Not Exclusive

WASHINGTON -- The so-called Schneiderian first-rank symptoms -- used as diagnostic criteria for schizophrenia since 1959 -- are more useful as prognostic clues, a researcher said here. full story

http://www.medpagetoday.com/MeetingCoverage/APA/tb/9350

Loss of Protective Barrier May Link DCIS to Invasive Breast Cancer

BOSTON -- Ductal carcinoma in situ progresses to invasive breast cancer because of the loss of a protective cellular barrier, leading to fibroblast-induced disintegration of milk duct walls, investigators here reported. full story

http://www.medpagetoday.com/HematologyOncology/BreastCancer/tb/9348

CME SPOTLIGHT

The Evolution and Role of Incretin-Based Therapeutics.
This activity reviews the pathogenesis of type 2 diabetes, the mechanisms by which incretin hormones affect glucose homeostasis, and the role of incretin-based therapeutics in the management of type 2 diabetes.
Source: SciMed New York [more]

Controversies and Consensus in the Management of HIV: Interactive Debates
Are NNRTI- or PI-based regimens the best choice for initial ARV therapy? If a patient is failing therapy, when should you switch? Do treatment experienced patients require 2 or 3 active ARV agents? Join us for thoughtful debates and lively discussion led by a panel of HIV experts.
Source: AdvancMed [more]

Targeted Cancer Therapy From Trial To Clinic
Join Drs. Balducci, Atkins, Cantley, and Herbst for an innovative and in-depth CME-certified Activity on how integration of targeted and conventional therapies for treating cancer is improving patient outcomes.
Source: The Physicians Academy For Clinical and Management Excellence [more]

Emerging Trends in the Treatment of Renal Cell Carcinoma
Drs. Michael B. Atkins, Bernard J. Escudier, and Gary R. Hudes lead this CME activity which examines current and evolving standards of care for the treatment of early stage and advanced renal cell carcinoma; best practices for optimal patient outcomes are also covered.
Source: The Physicians Academy For Clinical and Management Excellence [more]

Myeloma Landscape 2008: Highlights in Frontline Therapy, Transplantation, and Relapsed/Refractory Disease.
This activity reviews these trials as well as new developments in transplantation and relapsed/refractory therapies.
Source: Curatio CME Institute [more]

Free CME Mood Disorders Certificate Program - Earn up to 12.0 AMA PRA Category 1 Credits?
Chaired by Dwight L. Evans, MD, this online curriculum on depression and bipolar disorder presents research findings (including STAR*D and STEP-BD trials), information on current and emerging treatment options, expert insights, and more.
Source: Projects In Knowledge [more]

Evolution in the Use of Boosted PIs as First-line Therapy: Factors to Consider
Drs Graeme Moyle and Sharon Walmsley review studies that compare efficacy, safety, and metabolic parameters of PIs in head-to-head trials along with emerging data on drug-drug interactions and insulin resistance.
Source: AdvancMed [more]

Medical and Surgical Management of Aortic Valve Disease
Join Dr. Joseph E. Bavaria, MD and the team of University of Pennsylvania cardiology and surgery specialists in reviewing of all the important topics related to aortic valve conditions that a cardiovascular clinician faces on a daily basis.
Source: University of Pennsylvania School of Medicine [more]

NEEDS ASSESSMENT

Developments in the Field of Advanced Renal Cell Carcinoma
Share your opinion. It matters.

Drs. Robert J. Motzer, Robert A. Figlin, Daniel J. George, and Brian I. Rini invite you to share your opinion in this short survey to help shape the content of an upcoming CME activity on advanced renal cell carcinoma. Thank you in advance for your valuable feedback. Source: Scepter [more]

JOURNAL DOWNLOADS

First-line SUTENT® data recently published in NEJM
Read first-line SUTENT data in the New England Journal of Medicine. Get it at SUTENThcp.com Source: Pfizer [more]

RESOURCES

Explore the Possibilities in Type 2 Diabetes.
View efficacy studies: Type 2 diabetes efficacy research & 18 and 24-week study designs. Source: Merck [more]

Access information on more than 150 Pfizer products at PfizerPro.com
Pfizer medicines have a new home on the Web. Visit PfizerPro.com for information on more than 150 Pfizer products. Convenient access to full prescribing information, scientific literature, professional resources, patient education material, and more. Source: Pfizer [more]

Find comprehensive, up-to-date information about clinical trials in oncology with TrialTrove™
Visit www.rocheexchange.com to access TrialTrove™, a real-time global oncology clinical trials database. For your convenience, each trial summary describes the study design, inclusion and exclusion criteria, and where the research is being conducted. Source: Roche [more]

Review safety, efficacy and PIs for Pfizer oncology medicines; search clinical trials, review pipeline, and more
Visit PfizerOncology.com to access the latest reprints, slides, and other resources, organized by tumor type; efficacy, safety, and dosing for Pfizer oncology drugs; current oncology news; clinical trials suitable for your patients; and more. Source: Pfizer [more]

View product information to discover more about sequential therapy in early breast cancer
Efficacy - Safety - Dosing - Key reprints - Materials and tools - Easy-to-read prescribing information - Patient educational materials Source: Pfizer [more]