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PUTTING BREAKING MEDICAL NEWS INTO PRACTICE^®

Friday June 06, 2008

TODAY'S HEADLINES
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For the latest news, features, columns, video and audio reports and more, visit our home page at www.medpagetoday.com

A Little Sun May Prevent Type 1 Diabetes

SAN DIEGO -- Lack of exposure to the sun could play a role in development of type 1 diabetes, researchers here said. full story

http://www.medpagetoday.com/Endocrinology/Diabetes/tb/9718

Pfizer Defends Beleaguered Varenicline (Chantix)
NEW YORK -- With its antismoking drug varenicline (Chantix) under a cloud for allegedly sparking suicidal behavior and ideation, Pfizer took its case to the press today, defending the agent as contributing far more benefit than potential harm. full story

http://www.medpagetoday.com/ProductAlert/Prescriptions/tb/9724

ASCO: North American Trial Fails to Confirm Benefit for Irinotecan (Camptosar) in SCLC
CHICAGO -- Irinotecan (Camptosar) plus cisplatin (Platinol) failed to demonstrate a survival benefit in a large North American trial of patients with extensive-stage small-cell lung cancer. full story

http://www.medpagetoday.com/MeetingCoverage/ASCOMeeting/tb/9723

Farmers and Others Using Pesticides Show Higher Diabetes Risk

RESEARCH TRIANGLE PARK, N.C. -- Long-term exposure to a range of insecticides and herbicides is associated with an increased risk of diabetes, epidemiologists here said. full story

http://www.medpagetoday.com/Endocrinology/Diabetes/tb/9715

A Cocktail Now and Then Lowers Risk of Rheumatoid Arthritis

STOCKHOLM, Sweden -- Drinking a few alcoholic beverages a week reduces the risk of rheumatoid arthritis, researchers here said. full story

http://www.medpagetoday.com/Rheumatology/Arthritis/tb/9721

ASCO: Needles May Ease Morbidities of Head-and-Neck Cancer Treatment

CHICAGO -- Acupuncture may reduce shoulder pain and the dry mouth associated with treatment of head-and-neck cancer, according to a small study reported here. full story

http://www.medpagetoday.com/MeetingCoverage/ASCOMeeting/tb/9657

ASCO: Gefitinib (Iressa) Shows Benefit for NSCLC Adenocarcinomas
CHICAGO -- In advanced non-small-cell lung cancer, disease progression slowed significantly when gefitinib (Iressa) was given after first-line chemotherapy, a large Japanese study showed. full story

http://www.medpagetoday.com/MeetingCoverage/ASCOMeeting/tb/9720

ASCO: Sorafenib (Nexavar) Slows Progression in Heavily Treated NSCLC

CHICAGO -- Patients with non-small-cell lung cancer who’d already had several courses of chemotherapy had significant slowing of progression when treated with sorafenib (Nexavar), according to results of a small intergroup trial. full story

http://www.medpagetoday.com/MeetingCoverage/ASCOMeeting/tb/9719

ASCO: Extended Chemotherapy for NSCLC Yields Mixed Results
CHICAGO -- For patients with non-small-cell lung cancer, extending their course of chemotherapy improves progression-free survival but not overall survival and at a cost of more adverse events and reduced quality of life, data from a meta-analysis suggest. full story

http://www.medpagetoday.com/MeetingCoverage/ASCOMeeting/tb/9714

ASCO: Advanced NSCLC Progression Slowed by Pemetrexed (Alimta)
CHICAGO -- After primary chemotherapy, patients with advanced non-small-cell lung cancer had a significant improvement in progression-free survival with pemetrexed (Alimta) maintenance, a large study showed. full story

http://www.medpagetoday.com/MeetingCoverage/ASCOMeeting/tb/9717

ASCO: Platinum-Taxane Regimen No Benefit for Thymoma or Thymic Carcinoma
CHICAGO -- For treatment-naive advanced thymoma or thymic carcinoma, carboplatin (Paraplatin) and paclitaxel (Taxol) failed to achieve response rates approaching those reported in published trials of athracycline-based regimens. full story

http://www.medpagetoday.com/MeetingCoverage/ASCOMeeting/tb/9716

ASCO: Little Support Seen for CT Lung Cancer Screening
CHICAGO -- Controversy and lack of evidence for a mortality benefit have made physicians reluctant to embrace spiral computed tomography (CT) screening for lung cancer. full story

http://www.medpagetoday.com/MeetingCoverage/ASCOMeeting/tb/9713

CME SPOTLIGHT

Treating Beyond LDL: Effective Management of Dyslipidemia and Metabolic Syndrome
Join Drs. Vera Bittner, David Kountz, Michael Miller & Frank Sacks for a Live National Satellite Broadcast w/interactive Q&A who will discuss CHD, risks & strategies for prevention/ treatment of dyslipidemia and metabolic syndrome.
Source: The Chatham Institute [more]

Targeted Cancer Therapy From Trial To Clinic
Join Drs. Balducci, Atkins, Cantley, and Herbst for an innovative and in-depth CME-certified Activity on how integration of targeted and conventional therapies for treating cancer is improving patient outcomes.
Source: The Physicians Academy For Clinical and Management Excellence [more]

Evolution in the Use of Boosted PIs as First-line Therapy: Factors to Consider
Drs Graeme Moyle and Sharon Walmsley review studies that compare efficacy, safety, and metabolic parameters of PIs in head-to-head trials along with emerging data on drug-drug interactions and insulin resistance.
Source: AdvancMed [more]

Prophylaxis in Adults With Severe Hemophilia A: Emerging Paradigms for Optimal Therapy
The emergence of a population of relatively healthy adults with hemophilia A is one of the major challenges of hemophilia care today. How do we optimally manage this group of patients who are living longer than ever before?
Source: Scienta Healthcare Education [more]

Managing the Symptomatic Menopausal Patient in Primary Care: A Case-Based Approach
This interactive CME activity provides practical recommendations and the latest clinical evidence to improve the personalized care a women receives during menopause.
Source: Interstate Postgraduate Medical Association and MEV Healthcom, Inc. [more]

Diagnosing and Treating Osteoporosis: An Evidence-Based Approach
Listen as the expert faculty discusses information for approaching and managing patients with low bone mass and osteoporosis. Also included in complimentary CME series is the newsletter "Practical Strategies for Managing Osteoporosis: an Evidence-Based Approach to Risk Assessment and Treatment."
Source: Med-IQ [more]

Managing CardioMetabolic Complexities
You are invited to participate in the following free educational activity where you will learn about the interrelated factors contributing to the metabolic syndrome and novel therapeutic strategies aimed at attenuating cardiometabolic risk while delaying disease progression.
Source: SciMed New York [more]

Expert Insight Into: Difference in Treatment Outcome in Outpatients With Anxious Versus Nonanxious Depression
Free CME article review. Michael E. Thase, MD, examines findings from this STAR*D report on treatment and prognosis in patients with anxious vs. nonanxious depression. Axis 1 co-morbidities and implications for best treatment options in real-world practice settings are discussed.
Source: Projects In Knowledge [more]

Expert Insight Into: Facilitating Oral Chemotherapy Treatment and Compliance Through Patient/Family-Focused Education
Jon D. Herrington, PharmD, BCPS, BCOP, reviews a recent article that examined new challenges associated with oral cancer therapies that clinicians face in the areas of patient and family teaching about toxicity management and compliance.
Source: Projects In Knowledge [more]

Examining Myeloma Therapy in 2008: Applying the Findings of Phase 3 Trials Into Clinical Practice
Recent randomized trials in myeloma provide clinicians with clearer direction on choice of therapy. This case-based program helps clinicians apply the highest level of evidence to daily practice.
Source: Curatio CME Institute [more]

JOURNAL DOWNLOADS

Efficacy Data for CTCL Published in JCO
Efficacy Data for CTCL Published in JCO. Source: Merck. [more]

Find reprints including first-line SUTENT® data published in NEJM
Read first-line SUTENT data in the New England Journal of Medicine. Get it at SUTENThcp.com Source: Pfizer [more]

RESOURCES

Zoster can easily be mistaken for one of the many eruptions it can mimic
Dr. Andrew Weinstein. Click to hear my thoughts on zoster. Source: Merck [more]

Access clinically relevant literature about Pfizer medicines
Pfizer for Professionals features extensive scientific literature, including clinical study abstracts, reprints, and clinical trial compendia. Source: Pfizer [more]

Explore the Possibilities in Type 2 Diabetes.
View efficacy studies: Type 2 diabetes efficacy research & 18 and 24-week study designs. Source: Merck [more]

Learn how Starlix™ (nateglinide) helps control mealtime glucose surges in patients with Type 2 Diabetes
View this e-learning for the latest information on Starlix and order valuable resources including samples and patient education materials. Source: Novartis Pharmaceuticals Corporation [more]

View product information to discover more about sequential therapy in early breast cancer
Efficacy - Safety - Dosing - Key reprints - Materials and tools - Easy-to-read prescribing information - Patient educational materials Source: Pfizer [more]

Review information on Pfizer oncology drugs; access other useful resources?PfizerOncology.com
Visit PfizerOncology.com to access the latest reprints, slides, and other resources, organized by tumor type; efficacy, safety, and dosing for Pfizer oncology drugs; current oncology news; clinical trials suitable for your patients; and more. Source: Pfizer [more]

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CROI Meeting

CROI: HIV Drug Holidays Have Lasting Adverse Effect

CROI: Extended HIV Treatment for Babies Reduces Breast-Milk Risk

ICAAC Meeting

ICAAC: Hand Hygiene Slipping in Public Washrooms

ICAAC: Day Care Safer Thanks to Vaccines

IAS Meeting

IAS: Investigative Drugs Zero in on HIV Vulnerabilities

IAS: Novel HIV Entry Blocker Found Safe and Powerful

HIV/AIDS

Study Details Heart Risks from HIV Drugs

Head-to-Head Trial Confirms Efavirenz (Sustiva) as Leader for Initial HIV Therapy

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